Downregulation of p120 catenin in the mouse hippocampus contributes to the development of depression-like phenotypes.

ABSTRACT:

Background

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and one of the leading causes of disability worldwide. Neuroinflammation is strongly implicated in the pathophysiology of MDD, suggesting that regulators of neuroinflammatory signaling are feasible therapeutic targets. The CTNND1 gene encodes a member of the armadillo protein family termed p120 (or catenin delta) that functions in cell-cell adhesion and signal transduction, including among immune cells, suggesting immunomodulatory activity.

Results

We report that systemic injection of the bacterial toxin lipopolysaccharide (LPS) induced depression-like behaviors in mice while concomitantly activating the neuroinflammatory NF-κB signaling pathway, upregulating interleukin (IL)-1β expression,

SUBMITTER: Chen C 

PROVIDER: S-EPMC12619300 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature