Cardiovascular determinants of the 6-minute walk distance in cardiac transthyretin amyloidosis.

ABSTRACT:

Background

The six-minute walk distance (6MWD) is a measure of functional capacity and a frequently used endpoint in clinical trials investigating transthyretin amyloid cardiomyopathy (ATTR-CM). We evaluated the clinical utility of the 6MWD by quantifying the gap between the expected and observed physical performance and estimating its determinants.

Methods

Outpatients with wild-type (ATTRwt)-CM were investigated. Standardized echocardiographic, laboratory and clinical assessments were performed. A regression formula derived from a healthy local population sample was applied to predict the expected 6MWD. Associations with 6MWD were analyzed by linear regression, adjusted for age and height. Explanatory multivariable models using backward elimination, regularization and clini

SUBMITTER: Cejka V 

PROVIDER: S-EPMC12619313 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature