The effect of disrupted sleep on macrophage polarization: a systematic review and meta-analysis of animal studies.

ABSTRACT:

Objective

Based on the bidirectional relationship between sleep and macrophages in healthy and diseased states, this systematic review and meta-analysis investigated the effect of disrupted sleep on macrophage polarization.

Methods

A literature search was conducted in PubMed, Scopus, and Web of Science (WoS) databases up to October 2023, identifying English-language studies on disrupted sleep's effects on macrophage polarization. After screening and data extraction, the standardized mean difference (SMD) with a 95% Confidence Interval (CI) was calculated for M1 pro-inflammatory and M2 anti-inflammatory markers. Heterogeneity was assessed using Cochran's Q test and the I-square (I²) statistic, and subgroup analyses were performed. The methodological quality was ass

SUBMITTER: Askarzadeh M 

PROVIDER: S-EPMC12619322 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature