Association between 10-year atherosclerotic cardiovascular disease risk score and incident cardiovascular events across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from the China health and retirement longitudinal study (CHARLS).

ABSTRACT:

Background

The cardiovascular-kidney-metabolic (CKM) syndrome framework integrates cardiometabolic risks. However, longitudinal evidence on the association between atherosclerotic cardiovascular disease 10-year risk (ASCVD10 year) scores and cardiovascular events across CKM syndrome stages remains limited in large aging populations.

Methods

We analyzed data from 4,565 adults aged ≥ 45 years in the China Health and Retirement Longitudinal Study (CHARLS). ASCVD10 year scores were calculated using the China-PAR model at baseline (2012) and follow-up (2015), with cumulative risk scores derived accordingly. Participants were stratified into four trajectory clusters via k-means clustering based on ASCVD score dynamics. Logistic regression, restricted cubic spline models, subgroup

SUBMITTER: Li Z 

PROVIDER: S-EPMC12619338 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature