Associations of lipoprotein subclasses with all-cause and cardiovascular mortality: results of two independent cohorts with a 20 year follow-up.

ABSTRACT:

Background

Currently total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are used in clinical practice to estimate future cardiovascular risk. We assessed whether other lipoprotein subclasses also contribute to cause-specific and all-cause mortality in the general population.

Methods

Two independent cohorts of the Study of Health in Pomerania (SHIP-START and SHIP-TREND) were used. Participants were selected from population registration offices. The primary outcomes were all-cause, cardiovascular and cancer mortality. TC, total triglycerides (TG), phospholipids as well as the fractional concentrations of cholesterol, TG, phospholipids, and apolipoproteins of all lipoprotein subclasses were measured using nuclear magnetic resonance spectroscopy. Cox proporti

SUBMITTER: Fierfas F 

PROVIDER: S-EPMC12619359 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature