Causal links between congenital malformations, birth weight, and neuroblastoma: insights from Mendelian randomization.

ABSTRACT:

Background

While it is commonly observed that congenital malformations (CM), birth weight and neuroblastoma (NB) often co-occur clinically, there is a scarcity of studies investigating their relationship.

Aim

To investigate the causal relationship between CM, birth weight and NB using two-sample mendelian randomization (MR) analysis.

Methods

This study utilized data from the Genome-Wide Association Studies (GWAS) database for CM, birth weight, and NB. We identified and analyzed single nucleotide polymorphisms (SNPs) related to CM from various organ systems, ensuring robust instrumental variables through linkage disequilibrium (LD) and F-statistic testing. SNPs were further validated in GWAS Catalog to exclude weak variables. We employed various MR methods including in

SUBMITTER: Aierken A 

PROVIDER: S-EPMC12619367 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature