Cardiac arrest triggers IL-17-mediated neuroinflammation and astrocyte polarization: insights into pathogenesis and intervention.

ABSTRACT:

Introduction

Cardiac arrest (CA) is a life-threatening emergency with a global one-year survival rate of 2%-10%. Brain injury significantly impacts CA outcomes, and neuroinflammation is a key mediator of cerebral damage. Interleukin-17 (IL-17) has been implicated in multiple inflammatory disorders, yet its contribution to CA-induced cerebral damage remains undefined.

Objective

To elucidate the role of the IL-17 axis in CA-triggered neuroinflammation and to determine whether IL-17 blockade can attenuate hippocampal injury and improve neurologic recovery.

Methods

Asphyxial CA was induced in adult Sprague-Dawley rats followed by cardiopulmonary resuscitation. Blood-brain barrier (BBB) integrity, Th17 infiltration, astrocyte polarization, and downstream signaling were ass

SUBMITTER: Li S 

PROVIDER: S-EPMC12619368 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature