The dual antifungal and antibiofilm activities of β-carotene against multidrug-resistant Candida albicans induce wound healing in a diabetic rat model: an in vitro and in vivo study.

ABSTRACT:

Background

Diabetes mellitus renders patients susceptible to chronic wounds and fungal infections, such as Candida albicans infections. The treatment of C. albicans-infected diabetic wounds is often problematic due to drug resistance and biofilm formation. Therefore, we studied the impact of β-carotene on treating diabetic wounds infected with strong biofilm-forming multidrug-resistant (MDR) C. albicans.

Results

Our data showed that β-carotene (200 µg/ml) exhibited potent antifungal activity against the planktonic C. albicans cells, including MDR cells, with inhibition zones of 14 to 34 mm, which was emphasized by methylene blue staining and growth kinetics analysis. Using polystyrene plates and silicon catheter models, β-carotene showed a promising antibiofilm action by dis

SUBMITTER: Al-Monofy KB 

PROVIDER: S-EPMC12619372 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature