Selenium nanoparticles mitigate Cyclophosphamide-Induced premature ovarian failures in mice by activating PI3K/AKT signaling pathway and inhibiting ferroptosis.

ABSTRACT: The therapeutic role and mechanisms of selenium nanoparticles (SeNPs) in cyclophosphamide (CTX)-induced premature ovarian failure (POF) remain unclear. In the present study, female mice were treated with CTX to induce POF, followed by SeNPs administration for 14 consecutive days. Ovarian weight, index, and serum hormone levels were measured to assess ovarian function. Histological examination of ovarian tissues was conducted to examine morphological changes, folliculogenesis, DNA damage, and apoptosis. Transcriptomic analysis was performed to identify the underlying molecular mechanisms, with in vitro studies on ovarian granulosa cells employed to validate the findings. The results confirmed that SeNPs administration effectively restored ovarian morphology and function, increasing the numb

SUBMITTER: Liu G 

PROVIDER: S-EPMC12619377 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature