RNA interference mediated mortality in Aedes albopictus: a challenging journey toward species-specific vector control.

ABSTRACT:

Background

Aedes albopictus is a major vector of pathogens, including arboviruses, causing thousands of deaths annually. With no effective antiviral therapies and increasing concerns about the ecological impact of chemical insecticides, species-specific strategies, such as RNA interference (RNAi), are beneficial. Thus, identifying and validating target genes that induce mortality is essential. However, RNAi efficacy in Ae. albopictus is often inconsistent, owing to multiple factors including degradation by nucleases. Therefore, molecular identification and quantification of the underlying nucleases will provide a basis for improving RNAi efficacy.

Methods

Target genes were selected from previous studies, identified in Ae. albopictus, and their corresponding long double-stran

SUBMITTER: Omokungbe B 

PROVIDER: S-EPMC12619383 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature