Lung cancer and COVID-19 susceptibility and severity: a Mendelian randomization analysis.

ABSTRACT: It has been observed that lung cancer patients are more susceptible to COVID-19. Establishing the causal relationships between lung cancer and COVID-19 susceptibility and severity is challenging due to numerous confounding factors. Mendelian randomization (MR) is an effective method to investigate the causal association between exposure and outcome variables. However, different studies have yielded conflicting conclusions regarding the role of lung cancer in COVID-19 susceptibility and severity. Lung cancer subtypes exhibit heterogeneity in genetic susceptibility, which may influence the assessment of the true relationship between lung cancer and COVID-19 susceptibility and severity. In this study, we utilized the most recent COVID-19 association data from The COVID-19 Host Genetics Initia

SUBMITTER: Bai M 

PROVIDER: S-EPMC12619388 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature