A glucose time in range of 70% attenuates the senescence-inducing and pro-inflammatory effects of hyperglycemia.

ABSTRACT:

Background

The Time In Range (TIR) represents the amount of time spent by a given individual in the range close to normoglycemia, i.e. 70-180 mg/dl. On the basis of studies demonstrating an association of TIR with the incidence of diabetes complications, guidelines recommend a target of at least 70% of TIR for most people with diabetes. However, no study has explored the effect of variable degrees of TIR on molecular mechanisms relevant for the development of diabetes complications.

Methods

We exposed endothelial cells and monocytes to increasing percentages of TIR, i.e. 50%, 70%, 85% by changing cell media twice a day as appropriate, as well as to constant normoglycemia (i.e. fixed 100 mg/dl of glucose for endothelial cells) and hyperglycemia (i.e. 500 mg/dl glucose), evalu

SUBMITTER: La Grotta R 

PROVIDER: S-EPMC12619397 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature