Long-term trends in reporting of cardiac adverse drug reactions to COVID-19 vaccines - an exploratory analysis of the EudraVigilance database.

ABSTRACT:

Background

Vaccination against COVID-19 could be followed by a serious cardiac adverse drug reaction (SCADR), which is a noxious, unintended response to the administered vaccine and is life-threatening, usually requires hospitalisation and may result in death. We aimed to explore long-term trends in reporting of SCADRs to COVID-19 vaccines.

Methods

In this retrospective, longitudinal, observational study, suspected (potentially linked to vaccination) SCADRs to Comirnaty (Pfizer BioNTech), Spikevax (Moderna), Vaxzevria (AstraZeneca) and Jcovden (Janssen) vaccines were extracted from the EudraVigilance database (n = 87,000). This data was coupled with the corresponding weekly number of administered vaccine doses from the Vaccine Tracker database (n = 733,837,251).

Results</

SUBMITTER: Nazar W 

PROVIDER: S-EPMC12619418 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature