Body composition mediates the association between fatty acids and NAFLD risk: a prospective cohort study.

ABSTRACT:

Background

This study aimed to investigate how body composition, particularly adiposity distribution, mediates the association between circulating fatty acids (FAs) and the incidence of severe non-alcoholic fatty liver disease (NAFLD).

Methods

In the UK Biobank cohort, plasma FAs were measured using nuclear magnetic resonance spectroscopy in 107,593 participants at baseline. Cox regression models were utilized to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between FAs and the incidence of severe NAFLD. Additionally, mediation analyses were conducted to quantify the mediating effects of different body composition indices in these associations. Cross-sectional association of FAs with metabolic-associated fatty liver disease (MAFLD) and

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12619455 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature