Inflammatory tropism in COVID-19: a comparative analysis of Delta and Omicron variants.

ABSTRACT:

Background

The clinical presentation of COVID-19 varies significantly by viral variant; the Delta variant often causes severe lung inflammation, whereas Omicron tends to result in less severe respiratory disease but may more readily affect other organs. The autoimmune mechanisms behind these variant-specific complications, particularly the potential role of anti-neutrophil cytoplasmic (ANCA) antibodies, are still not well defined. This study investigated myeloperoxidase (MPO), proteinase 3 (PR3), and glomerular basement membrane (GBM) antibodies in patients infected with the Delta and Omicron SARS-CoV-2 variants to evaluate their associations with specific clinical complications, such as renal or respiratory involvement.

Methods

Samples were collected during Delta and Omicro

SUBMITTER: Samiei A 

PROVIDER: S-EPMC12619456 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature