LTCONS_00014107-miR-29b-2-3p-GPR37 axis promotes heat stimulation induced esophageal carcinogenesis.

ABSTRACT: Esophageal cancer is a common malignant tumor of the digestive system, and Esophageal squamous cell carcinoma (ESCC) is the major histological subtype of esophageal cancer. Multiple epidemiological evidence shows that consumption of hot temperature food and beverages is an important risk factor for developing ESCC, however, its underlying mechanism remains unclear. Herein, we constructed an animal model of esophageal precancerous lesions induced by heat stimulation in rats and simulated the human habit of eating hot food and drinks. Both LncRNA and miRNA expression of esophageal tissues were profiled by RNA-seq. We found LTCONS_00014107 was lowly expressed but miR-29b-2-3p was highly expressed in heat-induced ESCC and degradation of LTCONS_00014107 promoted the expression of miR-29b-2-3p s

SUBMITTER: Liu W 

PROVIDER: S-EPMC12619460 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature