Up-regulated WNT5A in PCOS affects steroidogenesis, proliferation and apoptosis of granulosa cells through the PI3K/AKT pathway.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in women of reproductive age and is characterized by a chronic state of excessive inflammation. Increased expression of WNT5A in a variety of diseases is thought to be related to inflammatory states. The purpose of this study was to explore the potential effects of WNT5A on ovarian granulosa cells and its potential role in the pathogenesis of PCOS.

Results

In this study, we found increased expression of WNT5A in the follicular fluid and granulosa cells (GCs) of PCOS patients undergoing in vitro fertilization-embryo transfer (IVF-ET). By constructing an animal model of PCOS, we verified the elevated expression of WNT5A and decreased expression of CYP19A1, a key enzyme for st

SUBMITTER: Li Y 

PROVIDER: S-EPMC12619470 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature