SGLT2 inhibitors and left atrial function in heart failure with reduced or mildly reduced ejection fraction.

ABSTRACT:

Background

Sodium-glucose cotransporter-2 (SGLT2) inhibitors reduce cardiovascular mortality and hospitalizations in heart failure (HF). However, their effects on left atrial (LA) structure and function remain unclear, particularly in patients with reduced or mildly reduced ejection fraction (EF).

Methods

This observational, cross-sectional study included 134 patients with HF and EF < 50%, divided into two groups: those receiving SGLT2 inhibitors (SGLT2+, n = 25) and those not receiving them (SGLT2-, n = 109). Echocardiographic measurements of LA volume index (LAVI), LA emptying fraction (LAEF), LA functional index (LAFI), and passive/active emptying fractions were obtained according to ASE/EACVI guidelines. Clinical, laboratory, and echocardiographic parameters were compare

SUBMITTER: Duman H 

PROVIDER: S-EPMC12619516 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature