Managing paraneoplastic GABA_BR-related limbic encephalitis in a patient with a small cell lung cancer receiving an Immune-Checkpoint Inhibitor (ICI) therapy: description of a case report.

ABSTRACT:

Introduction

GABA_B receptor (GABA_BR)-related paraneoplastic limbic encephalitis (PLE) is frequently associated with cancer, particularly small cell lung carcinoma (SCLC) and shows several clinical presentations often accompanied by distinctive MRI and EEG findings. It can be exacerbated by immune-modulating therapies, such as immune checkpoint inhibitors (ICIs) and needs a multidisciplinary approach.

Case report

This case report describes a 67-year-old male with a diagnosis of SCLC who developed a paraneoplastic LE. The patient's clinical presentation included amnesia, apraxia, and mesial temporal lobe seizure. MRI showed bilateral hippocampal involvement, and cerebrospinal fluid analysis revealed elevated protein levels and GABA_B-R antibodie

SUBMITTER: Cezar M 

PROVIDER: S-EPMC12619520 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature