Prophylactic laxative use for postoperative constipation in urological cancer: a real-world cohort study.

ABSTRACT:

Purpose

To assess the effectiveness of prophylactic laxative use compared to symptom-based management for preventing constipation in patients undergoing surgery for urological cancers.

Methods

Of 2,024 screened patients (aged 18-80) with urological tumors, 1,724 eligible (no severe gastrointestinal disease, non-pregnant, scheduled for surgery) were non-randomly assigned to prevention (prophylactic laxatives, n = 965) or non-prevention groups (symptom-based, n = 748). Propensity score matching with a 1:1 optimal matching strategy was used to minimize baseline differences between the two groups. The primary outcome was the incidence of constipation within 7 days post-surgery. Secondary outcomes included complete spontaneous bowel movements (CSBM), patient assessment of constip

SUBMITTER: Wahafu W 

PROVIDER: S-EPMC12619729 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature