Probiotic Engraftment of Akkermansia muciniphila in an In Vitro Synthetic Microbial Community.

ABSTRACT: Akkermansia muciniphila is a specialist mucin glycan-degrader that is common in the human gut. A. muciniphila is associated with host health and therefore proposed as a next-generation probiotic. However, it is unknown if consumption of live and active A. muciniphila will be effective in terms of survival and engraftment in the gut microbiome. Furthermore, it is of interest whether introduction of A. muciniphila would influence the resident mucosal microbiota. To this end, we investigate the addition of live A. muciniphila to a stable in vitro microbial mucin glycan-degrading synthetic community. A. muciniphila engrafted in this synthetic community and actively degraded mucin using essential mucin glycan-degrading enzymes. Addition of A. muciniphila did not induce major compositional chang

SUBMITTER: Berkhout MD 

PROVIDER: S-EPMC12619756 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature