Expansion of peripheral helper T cells in the peripheral blood of patients with chronic graft-versus-host disease.

ABSTRACT: Chronic graft-versus-host disease (cGVHD), presented as an autoimmune-like syndrome, is an important late complication and has become the leading cause of non-recurrent death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A cohort of 52 cGVHD patients were analyzed for the presence of Tph cells, circulating follicular helper T (cTfh) cells and B cells in peripheral blood mononuclear cells (PBMCs). We found decreased frequency of cTfh cells, but increased frequency of Tph cells in post-transplant patients compared to healthy controls (HCs). Higher percentage and absolute number of CCR2⁺Tph cells were observed in cGVHD patients. The percentage and absolute number of Tph cells decreased significantly with anti-cGVHD therapy. The percentage of Naive B cells, B

SUBMITTER: Du Y 

PROVIDER: S-EPMC12619759 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature