Isolated restricted diffusion in glioblastoma: incidence, progression, and survival impact '.

ABSTRACT:

Background

Glioblastoma (GB) is the most malignant primary brain tumor. Isolated restricted diffusion (IRD) is restricted diffusion outside the confines of enhancing tumor with no corresponding enhancement on post contrast study. The aim of our study was to prospectively assess the incidence of IRD in GB patients, determine how often these foci proceed to contrast enhancement on follow up, and analyze the survival pattern of patients with IRD.

Methods

In a prospective pilot cohort study, consecutive adult patients (≥ 18 years old) suspected of having GB on initial MRI of brain, were included and screened for the presence of IRD. All images were independently analyzed by two experienced radiologists for inter-rater reliability. The survival pattern of patients with IRD was as

SUBMITTER: Shankar J 

PROVIDER: S-EPMC12619763 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature