Role of viral coinfection in post-pandemic invasive Group A streptococcal infections in adults, a nation-wide cohort study (iGASWISS).

ABSTRACT:

Objective

During the winter season of 2022-2023, numerous countries experienced a surge in invasive Streptococcus pyogenes (iGAS) infections. The role of viral coinfections in the post-COVID surge has not been elucidated. We report nation-wide data describing clinical presentation, microbiological characteristics, and associations with viral infection in adults during this period.

Methods

A multicenter retrospective cohort study was conducted across 10 hospitals in Switzerland, including adults (> 16 years old) with iGAS infection from November 2022 to February 2023. Descriptive analysis was performed. A multivariable logistic regression model was fitted to assess the impact of viral coinfection. In addition, genetic analysis was performed in available isolates.

Results</

SUBMITTER: Musumeci S 

PROVIDER: S-EPMC12619775 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature