Impact of pneumococcal urinary antigen testing on clinical outcomes in patients hospitalized with community-acquired pneumonia.

ABSTRACT: To establish a microbiological etiology in severe community-acquired pneumonia (CAP), most guidelines recommend adding urinary antigen tests (UAT) to respiratory sampling. However, their usage and impact remain unclear. We examined the clinical impact of UAT in hospitalized CAP patients. This multicenter cohort study included patients admitted with CAP at three hospitals in Denmark from 2017 to 2020. Logistic regression and propensity-score matching were applied to assess the effect of UAT on 30-day mortality, targeted antibiotic treatment and atypical antibiotic coverage. Propensity-score matching was applied to adjust for confounding. Of 2,449 patients included, 654 (27%) had UAT performed within 48 hours of admission. Streptococcus pneumoniae was detected in 8.0% (52/654). 30-day mortal

SUBMITTER: Kern M 

PROVIDER: S-EPMC12619800 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature