Proteomic and metabolomic profiling of plasma reveals physiologic changes in patients with convalescent COVID-19.

ABSTRACT:

Background

This study aimed to analyze the molecular composition and physiological changes in the plasma of patients with convalescent coronavirus disease 2019 (COVID-19).

Methods

Plasma samples from 29 hospitalized patients recovering from COVID-19 and 30 uninfected controls were analyzed using untargeted metabolomics and data-independent acquisition mass spectroscopy proteomic analyses. Integrative metabolomic-proteomic analysis was then conducted to construct a protein-metabolite interaction network.

Results

Untargeted metabolomic profiles revealed 415 differential metabolites, with 28.05% of the metabolites belonging to lipids and lipid-like molecules, most of which were upregulated in patients with convalescent COVID-19, such as sphingolipids. Differential metabo

SUBMITTER: Wang L 

PROVIDER: S-EPMC12619808 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature