Aquagenic Pruritus Questionnaire: Predicting Myeloproliferative Neoplasms in Patients with Aquagenic Pruritus.

ABSTRACT:

Introduction

Aquagenic pruritus (AP) is an underrecognized condition in which patients perceive itch following contact with water on clinically non-lesional skin. AP is frequent in patients suffering from myeloproliferative neoplasms (MPN) such as polycythemia vera and may manifest several years prior to MPN diagnosis. To date, there is no validated patient-reported outcome measure (PROM) assessing AP and its association with MPN.

Methods

In this multiphase study, eight questions relevant to AP were developed and validated in 77 patients with AP and 50 patients with chronic non-aquagenic pruritus (CP). After reduction to those questions relevant for distinguishing between AP with and without MPN, the resulting questionnaire was validated in 76 patients with AP (37 with MPN)

SUBMITTER: Witte F 

PROVIDER: S-EPMC12619876 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature