StTrace: detecting spatial-temporal domains from spatial transcriptome to trace developmental path.

ABSTRACT: Development shapes the growth and organization of organisms, enabling the emergence of complex biological structures and functions. Investigating the development process is vital for uncovering the formation of complex biological systems. However, current approaches to studying development from gene expression rely primarily on single-cell gene expression data to infer developmental trajectories, neglecting the spatial distribution of cells within tissues and their interactions. Although spatial transcriptomics provides spatial context for gene expression, existing algorithms focus mainly on identifying spatial regions without further exploring their developmental connections. In this study, we propose an algorithm for detecting spatial-temporal domains in tissue to trace developmental pat

SUBMITTER: Song Z 

PROVIDER: S-EPMC12619910 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature