Infections preceding diagnosis associated with myositis phenotypes in a national patient registry.

ABSTRACT:

Objectives

We investigated the association of antecedent infections with clinical subgroups and phenotypes in the idiopathic inflammatory myopathies (IIMs).

Methods

Adult IIM patients (362 with dermatomyositis (DM), 250 with polymyositis (PM), and 256 with inclusion body myositis (IBM)) enrolled in a national myositis patient registry. One hundred thirty-four patients had symptoms of lung disease plus fever and/or arthritis (LD+), and 103 with systemic autoimmune rheumatic disease-associated overlap myositis (OM). Self-reported infections and antibiotic usage within 12 months prior to IIM diagnosis were examined. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated across IIMs. LD+ and OM analyses were performed excluding IBM patients.

Results

SUBMITTER: Ohnishi T 

PROVIDER: S-EPMC12619962 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature