A 12-Week Strength Training Improves Mitochondrial Respiration, H₂O₂ Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats in the DMPK gene, causing the accumulation of toxic RNA that sequesters RNA-binding proteins. Clinically, DM1 is characterized by progressive muscle weakness and atrophy, resulting in reduced physical capacity and quality of life. Recent evidence implicates mitochondrial dysfunction in DM1 pathophysiology. While aerobic exercise has been shown to improve skeletal muscle and mitochondrial health in individuals with DM1, the benefits of strength training remain unexplored.

Objectives

We investigated the effects of a 12-week strength training program on mitochondrial respiration, reactive oxygen species (ROS) production and muscle integrity in women with DM1.

Methods

Vastus lateralis muscle biop

SUBMITTER: Marcangeli V 

PROVIDER: S-EPMC12619986 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature