Cystatin C-Guided Dosing Nomogram Improves Target Attainment for Cefepime in the Critically Ill.

ABSTRACT:

Objectives

Estimated glomerular filtration rate is more accurate with combined creatinine and cystatin C equations (eGFR cr-cys ) than creatinine alone. This study created and evaluated a cefepime dosing nomogram based on eGFR cr-cys for initial dosing in the critically ill.

Design

Pharmacokinetic modeling and simulation study.

Setting

Academic medical center.

Patients

Critically ill adults treated with cefepime.

Interventions

None.

Measurements and main results

Data from 120 patients with baseline cystatin C and follow-up cefepime levels were used to develop a nomogram based on eGFR cr-cys and weight for initial cefepime dosing. The predicted proportion of patients who achieved a free cefepime concentration above the minimum inhibitory concentrat

SUBMITTER: Barreto EF 

PROVIDER: S-EPMC12620034 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature