Widespread gray and white matter microstructural alterations in dual cognitive-motor deficit.

ABSTRACT:

Introduction

Dual cognitive-motor deficit in aging is a strong predictor of dementia, yet its effects on vulnerable gray matter region microstructure remain unexplored.

Methods

This study classified 582 individuals aged 36 to 90 into cognitive-motor deficit, isolated cognitive or motor deficit, and control groups. Microstructural differences in 27 temporal and motor-related gray matter (GM) regions and white matter (WM) tracts were assessed using diffusion tensor imaging and mean apparent propagator, a technique well suited for GM analysis.

Results

We found widespread microstructural alterations among individuals with dual cognitive-motor deficit. These changes were not observed in isolated cognitive or motor deficits after multiple comparisons correction.

Discussi

SUBMITTER: Singh K 

PROVIDER: S-EPMC12620078 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature