Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria.

ABSTRACT:

Background

Previous studies on retinal changes in Alzheimer's disease (AD) using optical coherence tomography (OCT) and electroretinography (ERG) based on clinical diagnostic criteria have yielded inconsistent results. We evaluated retinal structure and function in subjects classified using clinical and biological definitions.

Methods

Fifty-nine included subjects underwent comprehensive neuropsychiatric and ophthalmic evaluations, including OCT and ERG with photopic negative response (PhNR). Amyloid status was determined by ¹¹C-Pittsburgh compound B positron emission tomography (PET).

Results

No significant differences in evaluated OCT and ERG parameters were found between cognitively impaired and unimpaired groups. Amyloid-positive subjects showed signific

SUBMITTER: Ariello LE 

PROVIDER: S-EPMC12620081 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature