Absolute quantification of cerebral metabolites using two-dimensional proton MR spectroscopic imaging with quantitative MRI-based water reference.

ABSTRACT:

Purpose

Metabolite concentrations are valuable biomarkers in brain tumors (BTs). However, absolute quantification of metabolites using MR spectroscopy requires a correction of water relaxation using time-consuming quantitative MRI (qMRI) sequences in addition to a lengthy two-dimensional spectroscopic water-reference acquisition. The goal of this work was to develop and validate a fast quantification method where a two-dimensional spectroscopic water reference is obtained using qMRI and a single-voxel stimulated-echo acquisition mode (STEAM) sequence.

Methods

The semi-adiabatic localization by adiabatic selective refocusing (sLASER) sequence was used for MR spectroscopy imaging (MRSI) acquisition. A single-voxel unsuppressed water signal was acquired using a STEAM sequence.

SUBMITTER: Thomas DC 

PROVIDER: S-EPMC12620158 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature