Free-breathing 3D pulmonary ventilation mapping at 0.55 T using stack-of-spiral out-in bSSFP.

ABSTRACT:

Purpose

To develop a free-breathing pulmonary imaging technique that provides three-dimensional (3D) structural images and regional ventilation maps, and to evaluate its repeatability and accuracy compared with two-dimensional phase-resolved functional lung (PREFUL) and global tidal volume.

Methods

A free-breathing 3D stack-of-spiral out-in (SOS out-in) balanced steady-state free precession (bSSFP) sequence with self-navigators was designed to achieve 2-mm isotropic resolution in 5 min. Respiratory-resolved images were reconstructed using spatial L1 wavelet and temporal finite-difference constraints. The 3D ventilation maps were generated based on Jacobian determinant of the estimated nonrigid deformations. Six healthy volunteers were scanned in supine and prone positions. V

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12620162 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature