A theoretical interpretation of diffusion weighted and intravoxel incoherent motion imaging for cerebrospinal fluid flow.

ABSTRACT:

Purpose

Diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) imaging are well-established approaches for evaluating cerebrospinal fluid (CSF) flow in subarachnoid and perivascular spaces, and have recently been applied to study ventricular CSF flow. However, DWI does not directly measure flow velocity, and the physical implications of DWI measurements are unclear. This study aimed to provide a theoretical interpretation of the DWI and IVIM imaging of CSF flow velocity fields.

Theory

The general semi-analytical form of the signal attenuations caused by fluid flow and the resultant apparent diffusion coefficient were derived from the Bloch-Torrey equation for arbitrary b$$ b $$ values.

Methods

The fundamental properties of the signal attenuation in l

SUBMITTER: Otani T 

PROVIDER: S-EPMC12620170 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature