Importance of R₂ accuracy in susceptibility source separation.

ABSTRACT:

Purpose

To examine the importance of R₂ accuracy on independent paramagnetic and diamagnetic outputs from susceptibility source separation in the brain from two publicly available methods.

Methods

The effects of R₂ errors, which translate into R2'$$ {\mathrm{R}}_2^{\prime } $$ errors, on output maps from χ-separation and χ-sepnet were examined using data from 11 healthy volunteers. Baseline R₂ values were determined by Bloch modeling a dual-echo turbo spin echo decay with measured flip angles. R₂ errors were introduced from either simple exponential fitting, R₂ multiplication factors, or R₂ approximation using only R2*$$ {\mathrm{R}}_2^{\ast } $$ . Altered R₂ maps were then used as input for the sus

SUBMITTER: Oliveira Assuncao TB 

PROVIDER: S-EPMC12620178 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature