Interpreting amide proton transfer-weighted imaging contrast between normal and tumor brain tissues using the asymmetry analysis method at 4.7 T.

ABSTRACT:

Purpose

To provide a comprehensive analysis of the contributors to the amide proton transfer-weighted (APTw) imaging signal using an asymmetry analysis method, as well as its contrast between tumors and the contralateral normal tissues at 4.7 T.

Methods

First, a signal model was developed to demonstrate the dependence of APTw signal on various contributors, including water T₁, reference signal containing direct water saturation (DS) and magnetization transfer (MT), as well as APT, amine CEST, and nuclear Overhauser enhancement (NOE) effects. Second, these effects were measured in rat brains bearing 9 L tumors, with saturation field strengths (B₁) of 2 and 3 μT, at 4.7 T to assess their relative contributions. Specifically, the reference signal was deter

SUBMITTER: Viswanathan M 

PROVIDER: S-EPMC12620183 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature