Do Patients Comply With 12-h Lithium Blood Level Timing? Findings From a Controlled Clinical Trial and a Real-World Clinical Setting.

ABSTRACT:

Background

Lithium blood levels are measured routinely 12 h after lithium dosing, but no study has evaluated the actual compliance of patients with the 12-h levels.

Methods

First, we used the US multicenter clinical trial "Bipolar CHOICE" (n = 145 patients treated with lithium with N = 287 lithium blood tests), where participants reported the time since the last lithium dose at lithium blood tests. Second, we included all lithium blood tests (3179 individuals, 52,837 blood tests) from hospitals and private practitioners in the Central Denmark Region (CDR, approximate population 1.3 million) during 2012-2022, including the time of lithium blood tests and the registered time when patients were supposed to take their lithium dose.

Results

In Bipolar CHOICE, participants

SUBMITTER: Jacobsen SL 

PROVIDER: S-EPMC12620334 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature