Interleukin 33 Promotes Liver Sinusoidal Endothelial Cell Dysfunction and Hepatic Fibrosis in Diabetic Mice.

ABSTRACT:

Backgruound

Interleukin 33 (IL33) drives liver fibrosis, and individuals with type 2 diabetes mellitus are more likely advanced to liver fibrosis. However, the role of IL33 in diabetic liver fibrosis remains unclear, prompting our investigation.

Methods

We developed a diabetes model in wild-type, IL33-/-, and suppression of tumorigenicity 2 (ST2-/-, IL33 receptor) mice. Furthermore, wild-type diabetic mice were injected with IL33 neutralizing antibody (αIL33). We also co-cultured human liver endothelial cells and human hepatic stellate cells to identify the role of IL33 in high palmitic acid and high glucose conditions.

Results

Hepatic collagen deposition was increased in diabetic mice, which was alleviated by IL33 knockout, ST2 knockout, or administration of αIL33. A

SUBMITTER: Chen H 

PROVIDER: S-EPMC12620701 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature