Electrically active hydrogels based on PEDOT:PSS for neural cultures.

ABSTRACT: Electrically active hydrogels are attracting significant interest as biohybrid materials for electrical interfacing with biological tissues. Here, we report the development of electrically active hydrogels, specifically engineered for in vitro neural cell cultures. The hydrogels' matrix comprises a viscoelastic alginate primary network, interpenetrated by a secondary network formed by the neural cell-adhesive protein, laminin. Conducting poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) particles are embedded throughout the hydrogel matrix, serving as the electrically active filler phase. Oscillatory rheology confirmed the viscoelastic nature of the composite hydrogels, with storage and loss moduli in the range of 1-10 kPa, suitable for neural tissue interfacing. Th

SUBMITTER: Wang L 

PROVIDER: S-EPMC12620795 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature