Longitudinal plasma proteomics: relation to incident Alzheimer's disease dementia and biomarkers.

ABSTRACT:

Introduction

We investigated whether longitudinal changes in plasma proteins were associated with baseline cognitive stages related to Alzheimer's disease (AD), their progression, and AD biomarkers.

Methods

We analyzed longitudinal proteomics (SomaScan 7K) data (N = 347) from the Indiana AD Research Center using linear mixed-effects models for associations with baseline cognitive stages, AD dementia (ADD) conversion, and AD imaging/plasma biomarkers, followed by machine learning analysis to evaluate predictive performance for incident ADD.

Results

Our analysis identified two proteins (ACES and IGFALS) associated with baseline diagnosis stages and six proteins (ACES, C7, ZCD1, IL-17C, CC055, and SO5A1) associated with incident ADD. Longitudinal changes of the identifie

SUBMITTER: Lee EH 

PROVIDER: S-EPMC12621001 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature