A novel microcapsule composite Spherulites Peony Superior Retinol mitigates UVB-induced skin damage in vitro and in vivo.

ABSTRACT: Skin serves as our outermost barrier, protecting our bodies from various environmental damages. Increasing research has revealed that UVB is a primary factor for extrinsic aging. This study explored the role of a novel microcapsule composite Spherulites Peony Superior Retinol (SPSR) on skin damage induced by UVB. SPSR exhibited a capacity to eliminate UVB-induced ROS. By measurement of cyclobutane pyrimidine dimers (CPD) and comet assay, the results implied that SPSR mitigates DNA damage from oxidative damage caused by UVB. In addition, UVB radiation typically leads to an increase in inflammatory factors within the skin. Decreased gene expressions of interleukin-1α and TNF-α have been observed in HaCaT cells. Moreover, a decreased gene expression of extracellular matrix (ECM)-related prote

SUBMITTER: Han J 

PROVIDER: S-EPMC12621075 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature