CD8⁺ T Cells Negatively Modulate Ischemia-Induced Angiogenesis in Mice.

ABSTRACT: Angiogenesis-related therapeutic approaches to peripheral arterial disease (PAD) deserve attention. CD8⁺ T cells play important roles in human pathobiology, and we investigated the involvement of cytotoxic CD8⁺ T cells in angiogenesis in response to ischemic stress. We also examined the mechanism of a component of green tea catechins, epigallocatechin-3-gallate (EGCG), which facilitates vascular regeneration in mice. Male 8-week-old wild-type [(CD8a^+/+) and interferon-gamma (IFN-γ^+/+)] knockout (CD8a^-/- and IFN-γ^-/-) mice were subjected to unilateral hindlimb ischemic surgery and then loss-of-function studies by blood flow, molecular, and immunostaining analyses at several time points. Post-ischemic surgery CD8a^+/+

SUBMITTER: Piao X 

PROVIDER: S-EPMC12621164 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature