Higher afamin concentrations are associated with higher fatty liver indices: Population-based KORA F4/FF4 study.

ABSTRACT:

Background

Previous studies suggest that afamin is associated with steatotic liver diseases (SLD). However, the exact role of afamin in SLD development and fibrogenesis remains unclear. Potential modifying effects of sex and glucose tolerance status have also not been examined. Therefore, we investigated the associations of afamin with steatotic liver diseases and fibrosis defined by non-invasive tests and assessed for possible effect modifications.

Methods

This study included 3080 participants from the population-based KORA F4/FF4 cohort. Cross-sectional and prospective associations (follow-up time 6.5 years) between afamin and NAFLD liver fat score (NAFLD LFS), hepatic steatosis index, fatty liver index and the fibrosis-4 index were assessed using multiple linear regressio

SUBMITTER: Niersmann C 

PROVIDER: S-EPMC12621296 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature