Ranking the most efficient human papillomavirus vaccination strategies in low-income and lower-middle income countries: a mathematical modelling analysis.

ABSTRACT:

Background

One-dose vaccination and increased vaccine supply provide the opportunity for low-income countries (LICs) and lower-middle-income countries (LMICs) to extend human papillomavirus (HPV) vaccination to populations other than girls aged 9-14 years targeted by routine vaccination. The aim of our study was to use mathematical modelling to identify and rank HPV vaccination strategies according to their efficiency at reducing cervical cancer in LICs and LMICs.

Methods

In this mathematical modelling analysis, we used HPV-ADVISE to model the efficiency of 162 vaccination strategies in 67 LICs and LMICs varying the following parameters: targeted populations (girls and women or gender neutral); age cohorts (routine vaccination at age 9 years or multi-age cohorts up to age 14

SUBMITTER: Benard E 

PROVIDER: S-EPMC12621302 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature