Stage-sensitive potential of isolated rabbit ICM to differentiate into extraembryonic lineages†.

ABSTRACT: In the course of mammalian development, the initial state of totipotency must be lost to allow the acquisition of specific cell fates. The first differentiation event results in the formation of trophectoderm (TE) and the inner cell mass (ICM). In the mouse embryo, the cell fate of these two compartments is set quickly after blastocyst formation. However, recent reports suggest that the plasticity of these two lineages might be extended in species other than the mouse. Here, we investigated how the cellular plasticity of early mammalian embryos relates to developmental time scale and changes in gene expression using rabbit isolated ICMs. We studied the dynamics of rabbit blastocyst formation using time-lapse imaging and identified GATA3 as an early marker of rabbit TE and CDX2 as a marker

SUBMITTER: Filimonow K 

PROVIDER: S-EPMC12621310 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature