Association between estimated plasma volume status and risk of sepsis-associated acute kidney Injury: a retrospective cohort study using the MIMIC-IV database.

ABSTRACT: Estimated plasma volume status (ePVS) is a simple, useful tool for assessing volume status. However, its prognostic value in sepsis-associated acute kidney injury (SA-AKI) remains unclear. This retrospective cohort study analyzed data from 15,789 patients with SA-AKI extracted from the MIMIC-IV database. The association between ePVS and mortality was evaluated using Cox regression and Kaplan-Meier analysis. Logistic regression was employed to assess the relationship between ePVS and renal recovery. All models were adjusted for demographics, comorbidities, laboratory values, and illness severity scores. Restricted cubic spline (RCS) model was applied to examine potential nonlinear relationships between ePVS and mortality risk. Among 15,789 eligible patients with SA-AKI, the 28-day mortality

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12621331 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature