Comprehensive clinical analysis of gastric-type endocervical adenocarcinoma: a real-world multicenter study.

ABSTRACT:

Background

Gastric-type endocervical adenocarcinoma (G-EAC) is a rare malignancy, and its clinicopathological characteristics remain poorly defined. This study aimed to evaluate the real-world features, treatment patterns, and outcomes of patients with G-EAC.

Methods

Clinical data from 124 patients diagnosed with G-EAC between 2012 and 2024 across four tertiary hospitals in China were retrospectively analyzed. Clinicopathological features, therapeutic approaches, and survival outcomes were assessed. Overall survival (OS) was the primary endpoint. Kaplan-Meier and Cox regression analyses were performed to identify prognostic factors.

Results

The median diagnostic age was 55 years (range, 33-82). At presentation, 62.1% of patients had invasion or metastasis, most common

SUBMITTER: Chang L 

PROVIDER: S-EPMC12621345 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature