Phased epigenomics and methylation inheritance in a historical Vitis vinifera hybrid.

ABSTRACT:

Background

Epigenetic modifications, such as DNA methylation, regulate transcription and influence key biological traits. While many efforts were made to understand their stability in annual crops, their long-term persistence in clonally propagated plants remains poorly understood. Grapevine (Vitis vinifera) provides a unique model, with cultivars vegetatively propagated for centuries.

Results

Here, we assemble the phased genomes of Cabernet Sauvignon and its parental lineages, Cabernet Franc and Sauvignon Blanc, using HiFi long-reads and a gene map tenfold denser than existing maps. Using three clones per cultivar, we quantify methylation with very consistent short- and long-read sequencing and ensure both varietal representativeness and assessment of clonal variability. We

SUBMITTER: Cochetel N 

PROVIDER: S-EPMC12621364 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature